LOXORAL® (30-4774)



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One Compounding Base That Does It All.

LoxOral gives you more bang for your base. It’s an all-in-one excipient base that can be used in oral capsule compounding formulas with many types of active pharmaceutical ingredients (APIs), including static prone and poorly soluble drugs. LoxOral now carries the USP Verified Mark for Excipients. This Mark is awarded only after USP's strict testing and evaluation criteria have been met, which includes:

  • A facility audit to ensure compliance with current Good Manufacturing Practices (cGMP)
  • Review of manufacturing and quality control documentation
  • Independent laboratory testing of product samples

Key Benefits & Features

  • Saves Time: Easily mixes with many types of APIs and allows powders to fall more easily and faster into the capsules than when using alternate fillers such as lactose or microcrystalline cellulose.
  • Reduces Static: Some APIs such as progesterone are known to be quite static-prone. LoxOral helps reduce static and clumping and improves flowability.
  • Even Distribution: Well-defined, uniform particle size creates improved distribution of the API within the base.
  • Improved Dissolution: Enhances the release of many types of APIs — including poorly soluble drugs — potentially leading to improved absorption.
  • USP Verified Excipient: Meets USP's program requirements for quality, consistency and compliance — so you can compound with even greater confidence for your patients.

Resources

Infographic

PCCA Science

Common APIs

  • Ketotifen
  • Liothyronine
  • Levothyroxine
  • Minoxidil
  • Naltrexone HCI
  • Progesterone
  • Sodium

Ideal in formulations for

  • All oral-capsule formulations
  • General systemic
  • Veterinary medicine
  • Hormone replacement therapy (HRT)

Formulated without

  • Gluten
  • Casein
  • Sodium lauryl sulfate (SLS)
  • Lactose
  • Soy
  • Corn
  • Dye
  • Magnesium stearate
 

PCCA Quality
Every day, we make a choice to define ourselves by high quality, not low price. We want to do everything we can to help you give your patients reproducible results and the best clinical outcomes possible, because your patients and your pharmacy matter to us. That’s why, every day, we choose to go above and beyond what is required and hold ourselves to The PCCA Standard™.

Frequently Asked Questions

LoxOral is the only excipient base needed for most types of APIs used in capsule formulations. This all-in-one base acts not only as a filler, but also improves dissolution, flowability and stability of the preparation. Plus, LoxOral is free of sodium lauryl sulfate, a common irritant that is found in other products on the market.

Common capsule fillers are lactose or microcrystalline cellulose. These agents act only as capsule fillers and lack the additional benefits that LoxOral provides, such as improving dissolution and flowability, reducing static and promoting stability.

On the Members-Only Website > Resources > Formula Tools. Select the Capsule Calculator and enter in your preferred ingredients’ lot numbers to have access to the latest available packing statistics. Alternatively, you can also search by the ingredient names or part numbers then select the appropriate lot numbers.

LoxOral is an immediate-release excipient base; however, it can easily be combined with Methocel E4M (40% in a size #1 capsule or larger is recommended) to create a slow-release capsule.

Yes, but due to the complexity of PCCA LoxOral, the low setting should be used (unless otherwise directed on a PCCA formula) to reduce clumping of the base on the lid or within the jar.

Yes.

Yes.

Yes.

  • Not a dangerous good in sense of transport regulations.

Caution: *NOTICE: DESICCANTS INSIDE* - FOR USE AS AN EXCIPIENT

Test Specification
DESCRIPTION WHITE POWDER; CHARACTERISTIC ODOR
SOLUBILITY INSOLUBLE IN WATER; INSOLUBLE IN ALCOHOL; INSOLUBLE IN METHANOL