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Monday, 02 December 2013 15:04

Technical Report: Characterization of the Physical and Microbiological Properties of LoxaSperse™

Introduction:

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LoxaSperse is a proprietary blend of micronized xylitol and micronized poloxamers, designed to be mixed with active substances in order to improve their water solubility and dispersibility. The use of xylitol and poloxamers in nebulization and irrigation is thoroughly referenced in the literature and there is ample evidence for their safety and efficacy (Durairaj et al., 2006; Plataki et al., 2011). Xylitol and poloxamers exhibit antimicrobial activity and, therefore, LoxaSperse is also expected to prevent microbial growth (Veyries et al., 2000; Zabner et al., 2000). LoxaSperse mixtures are dry powders, packaged as non-sterile capsules or sachets for dispersion or dissolution in sterile water prior to the administration of compounded medicines for nebulization and irrigation.

Abstract:

LoxaSperse is a proprietary blend of micronized xylitol and poloxamers, designed to be mixed with active substances in order to improve water solubility, dispersibility, and to prevent microbial growth. The physical and microbiological properties of LoxaSperse were characterized by three laboratory tests performed with LoxaSperse and LoxaSperse with itraconazole.

Conclusion:

LoxaSperse with itraconazole has improved particle size distribution in sterile water and also improved antifungal activity compared to itraconazole alone. Considering the MIC and aw of LoxaSperse, it is also concluded that LoxaSperse prevents microbial growth as expected.

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